Giridharan Periyasamy

Giridharan Periyasamy, Ph.D.

Genome Institute of Singapore
Singapore

Dr. Periyasamy is a platform head at the Centre for High Throughput Phenomics (CHiP-GIS) at the Genome Institute of Singapore. His research focuses on the cancer biology, drug resistance, and signaling pathway networks of human diseases as well as on ways to model these disorders. His current specific interest is the elucidation of novel mechanisms of drug resistance through the discovery/identification of novel gene function(s) and phenotypes using RNAi-mediated gene silencing or cDNA overexpression. He is also developing a robust and comprehensive panel of 3-D cell culture models from patient-derived primary cells that can be used to characterize different disease phenotypes and investigate the chemo-response of cells to novel or known drugs. The hope is that this work can lead to the establishment of an array of next generation preclinical 3-D tissue models for predictive toxicology screening and validation. Prior to his current position, Dr. Periyasamy worked as a scientific director of the HTS/HCS Screening Core Facility at the National Centre for Biological Sciences in India and was a group leader at Piramal Life Sciences in Mumbai, India. He studied at the Centre for Biotechnology at Anna University in Chennai, India, where he obtained his Ph.D. in biotechnology.